Publications

40. Fragment-based discovery of a new family of non-peptidic small-molecule cyclophilin inhibitors with potent antiviral activities.
Ahmed-Belkacem A, Colliandre L, Ahnou N, Nevers Q, Gelin M, Bessin Y, Brillet R, Cala O, Douguet D, Bourguet W, Krimm I, Pawlotsky JM, Guichou JF.
Nat Commun. 2016 Sep;7:12777.

39. Identification of Noncompetitve inhibitors of Cytosolic 5′-Nucleotidase II Using a Frament-Based Approach.
Marton Z, Guillon R, Krimm I, Preeti, Rahimova R, Egron D, Jordheim LP, Aghajari N, Dumontet C, Perigaud C, Lionne C, Peyrottes S, Chaloin L.
J Med Chem. 2015 Dec; 58(24):9680-96.

38. Ligand-Orientation Based Fragment Selection in STD NMR Screening.
Cala O., Krimm I.
J Med Chem. 2015 Nov; 58(21):8739-42

37. Overview of Probing Protein-Ligand Interaction Using NMR
Aguirre C, Cala O, Krimm I.
Curr Protoc Protein Sci 2015 Aug;81:17.18.1-17.18.24

36. A Combination of Spin Diffusion Methods for the Determination of Protein-Ligand Complex Structural Ensembles
Pilger J, Mazur A, Monecke P, Schreuder H, Elshorst B, Bartoschek S, Langer T, Schiffer A, Krimm I, Wegstroth M, Lee D, Hessler G, Wendt KU, Becker S, Griesinger C.
Angew Chem Int Ed Engl. 2015 Apr 15

35. Performance of Protein-Ligand Docking with Simulated Chemical Shift Perturbations
Ten Brink T, Aguirre C, Exner TE, Krimm I.
J Chem Inf Model. 2014 Oct 30

34. Protein-ligand structure guided by backbone and side-chain proton chemical shift perturbations
Aguirre C, Ten Brink T, Cala O, Guichou JF,Krimm I.
Journal of biomolecular NMR 2014 Nov;60(2-3):147-56

33. Comparing binding modes of analogous fragments using NMR in fragment-based drug design: application to PRDX5
Aguirre C, TenBrink T, Guichou JF, Cala O, Krimm I.
PLoS One. 2014 Jul 15;9(7):e102300

32. NMR-based analysis of protein-ligand interactions
Cala O, Guillière F, Krimm I.
Anal Bioanal Chem. 2014 Feb;406(4):943-56

31. BcL-xL conformational changes upon fragment binding revealed by NMR
Aguirre C, Ten Brink T, Walker O, Guillière F, Davesne D, Krimm I.
PLoS One. 2013 May 23;8(5):e64400

30. INPHARMA-based identification of ligand binding site in fragment-based drug design
Krimm I.
Med. Chem. Commun. (2012), 3, 605-610

29. Competitive binding of UBPY and ubiquitin to the STAM2 SH3 domain revealed by NMR
Lange A, Ismail MB, Rivière G, Hologne M, Lacabanne D, Guillière F, Lancelin JM, Krimm I, Walker O.
FEBS Lett. 2012 Sep 21;586(19):3379-84

28. Binding evaluation of fragment-based scaffolds for probing allosteric enzymes
Krimm I, Lancelin JM, Praly JP.
J Med Chem. 2012 Feb 9;55(3):1287-95

27. Ligand specificity, privileged substructures and protein druggability from fragment-based screening
Barelier S, Krimm I.
Curr Opin Chem Biol. 2011 Aug;15(4):469-74.

26. Ligand specificity in fragment-based drug design
Barelier S, Pons J, Gehring K, Lancelin JM, Krimm I.
J Med Chem. 2010 Jul 22;53(14):5256-66

25. Discovery of fragment molecules that bind the human peroxiredoxin 5 active site
Barelier S, Linard D, Pons J, Clippe A, Knoops B, Lancelin JM, Krimm I.
PLoS One. 2010 Mar 17;5(3):e9744

24. Fragment-based deconstruction of Bcl-xL inhibitors
Barelier S, Pons J, Marcillat O, Lancelin JM, Krimm I.
J Med Chem. 2010 Mar 25;53(6):2577-88

23. NMR screening applied to the fragment-based generation of inhibitors of creatine kinase exploiting a new interaction proximate to the ATP binding site
Bretonnet AS, Jochum A, Walker O, Krimm I, Goekjian P, Marcillat O, Lancelin JM.
J Med Chem. 2007 Apr 19;50(8):1865-75

22. Protein-protein interactions within peroxiredoxin systems
Noguera-Mazon V, Krimm I, Walker O, Lancelin JM.
Photosynth Res. 2006 Sep;89(2-3):277-90

21. Glutathionylation induces the dissociation of 1-Cys D-peroxiredoxin non-covalent homodimer
Noguera-Mazon V, Lemoine J, Walker O, Rouhier N, Salvador A, Jacquot JP, Lancelin JM, Krimm I.
J Biol Chem. 2006 Oct 20;281(42):31736-42

20. F-ara-AMP is a substrate of cytoplasmic 5′-nucleotidase II (cN-II): HPLC and NMR studies of enzymatic dephosphorylation
Jordheim LP, Cros E, Galmarini CM, Dumontet C, Bretonnet AS, Krimm I, Lancelin JM, Gagnieu MC.
Nucleosides Nucleotides Nucleic Acids. 2006 Mar;25(3):289-97

19. NMR of redox proteins of plants, yeasts and photosynthetic bacteria
Trivelli X, Bouillac S, Tsan P, Krimm I, Lancelin JM.
Photosynth Res. 2004;79(3):357-67

18. NMR reveals a novel glutaredoxin-glutaredoxin interaction interface
Noguera V, Walker O, Rouhier N, Jacquot JP, Krimm I, Lancelin JM.
J Mol Biol. 2005 Oct 28;353(3):629-41

17. HalX: an open-source LIMS (Laboratory Information Management System) for small- to large-scale laboratories
Prilusky J, Oueillet E, Ulryck N, Pajon A, Bernauer J, Krimm I, Quevillon-Cheruel S, Leulliot N, Graille M, Liger D, Trésaugues L, Sussman JL, Janin J, van Tilbeurgh H, Poupon A.
Acta Crystallogr D Biol Crystallogr. 2005 Jun;61(Pt 6):671-8

16. Crystal structure and solution NMR dynamics of a D (type II) peroxiredoxin glutaredoxin and thioredoxin dependent: a new insight into the peroxiredoxin oligomerism
Echalier A, Trivelli X, Corbier C, Rouhier N, Walker O, Tsan P, Jacquot JP, Aubry A, Krimm I, Lancelin JM.
Biochemistry. 2005 Feb 15;44(6):1755-67

15. Design of a data model for developing laboratory information management and analysis systems for protein production
Pajon A, Ionides J, Diprose J, Fillon J, Fogh R, Ashton AW, Berman H, Boucher W, Cygler M, Deleury E, Esnouf R, Janin J, Kim R, Krimm I, Lawson CL, Oeuillet E, Poupon A, Raymond S, Stevens T, van Tilbeurgh H, Westbrook J, Wood P, Ulrich E, Vranken W, Xueli L, Laue E, Stuart DI, Henrick K.
Proteins. 2005 Feb 1;58(2):278-84

14. 1H, 13C and 15N resonance assignments of poplar phloem glutaredoxin
Noguera V, Rouhier N, Krimm I, Jacquot JP, Lancelin JM.
J Biomol NMR. 2004 Oct;30(2):219-20

13. 1H, 13C and 15N backbone resonance assignments of the dimeric yeast peroxiredoxin YLR109w
Trivelli X, Krimm I, Verdoucq L, Chartier Y, Tsan P, Meyer Y, Lancelin JM.
J Biomol NMR. 2004 Jan;28(1):95-6

12. Characterization of the yeast peroxiredoxin Ahp1 in its reduced active and overoxidized inactive forms using NMR
Trivelli X, Krimm I, Ebel C, Verdoucq L, Prouzet-Mauléon V, Chartier Y, Tsan P, Lauquin G, Meyer Y, Lancelin JM.
Biochemistry. 2003 Dec 9;42(48):14139-49

11.The carboxyl-terminal region common to lamins A and C contains a DNA binding domain
Stierlé V, Couprie J, Ostlund C, Krimm I, Zinn-Justin S, Hossenlopp P, Worman HJ, Courvalin JC, Duband-Goulet I.
Biochemistry. 2003 May 6;42(17):4819-28

10. The Ig-like structure of the C-terminal domain of lamin A/C, mutated in muscular dystrophies, cardiomyopathy, and partial lipodystrophy
Krimm I, Ostlund C, Gilquin B, Couprie J, Hossenlopp P, Mornon JP, Bonne G, Courvalin JC, Worman HJ, Zinn-Justin S.
Structure. 2002 Jun;10(6):811-23

9. 1H, 13C and 15N resonance assignments of the C-terminal domain of human lamin A/C
Krimm I, Couprie J, Ostlund C, Worman HJ, Zinn-Justin S.
J Biomol NMR. 2002 Apr;22(4):371-2

8. NMR structures of thioredoxin m from the green alga Chlamydomonas reinhardtii
Lancelin JM, Guilhaudis L, Krimm I, Blackledge MJ, Marion D, Jacquot JP.
Proteins. 2000 Nov 15;41(3):334-49

7. Structural implications on the interaction of scorpion alpha-like toxins with the sodium channel receptor site inferred from toxin iodination and pH-dependent binding
Gilles N, Krimm I, Bouet F, Froy O, Gurevitz M, Lancelin JM, Gordon D.
J Neurochem. 2000 Oct;75(4):1735-45

6. Direct NMR observation of the thioredoxin-mediated reduction of the chloroplast NADP-malate dehydrogenase provides a structural basis for the relief of autoinhibition
Krimm I, Goyer A, Issakidis-Bourguet E, Miginiac-Maslow M, Lancelin JM.
J Biol Chem. 1999 Dec 3;274(49):34539-42

5. A coil-helix instead of a helix-coil motif can be induced in a chloroplast transit peptide from Chlamydomonas reinhardtii
Krimm I, Gans P, Hernandez JF, Arlaud GJ, Lancelin JM.
Eur J Biochem. 1999 Oct 1;265(1):171-80

4. Biochemical characterization and nuclear magnetic resonance structure of novel alpha-conotoxins isolated from the venom of Conus consors
Favreau P, Krimm I, Le Gall F, Bobenrieth MJ, Lamthanh H, Bouet F, Servent D, Molgo J, Ménez A, Letourneux Y, Lancelin JM.
Biochemistry. 1999 May 11;38(19):6317-26

3. NMR structures and activity of a novel alpha-like toxin from the scorpion Leiurus quinquestriatus hebraeus
Krimm I, Gilles N, Sautière P, Stankiewicz M, Pelhate M, Gordon D, Lancelin JM.
J Mol Biol. 1999 Jan 29;285(4):1749-63

2. NMR Structures of an alpha-like toxin from the Scorpion Leiurus quinquestriatus hebraeus.
Krimm I, Gilles N, Sautiere P, Stankiewicz M, Pelhate M, Gordon D and Lancelin J-M.
Toxicon, 37 (1999), 1226-1227.

1. The single mutation Trp35–>Ala in the 35-40 redox site of Chlamydomonas reinhardtii thioredoxin h affects its biochemical activity and the pH dependence of C36-C39 1H-13C NMR
Krimm I, Lemaire S, Ruelland E, Miginiac-Maslow M, Jaquot JP, Hirasawa M, Knaff DB, Lancelin JM.
Eur J Biochem. 1998 Jul 1;255(1):185-95